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Knauf C, Cani PD, Perrin C, et al

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A blood flow-obstructing clot that develops in a coronary artery can lead to acute coronary syndrome (unstable angina or heart attack), and in a cerebral artery, it can cause a stroke

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However, in women it occurs more commonly on the extremities, and in men it occurs most commonly on the trunk or head and neck.[4] Early signs in a nevus that would suggest a malignant change include: Darker or variable discoloration